教授

    • 姓名:瞿 昊
    • 职务:
    • 职称:教授、博士生导师
    • 所属系:食品质量安全系
    • 邮箱:quhao@hfut.edu.cn
    • 办公地点:食生楼602
  • 个人简介
  • 研究领域
  • 科研项目
  • 学术成果
  • 荣誉奖项

学习经历:

2001年09月-2005年07月中国科学技术大学(物理系)学士

2006年09月-2008年03月美国加利福尼亚大学洛杉矶分校(物理系)硕士

2008年03月-2012年09月美国加利福尼亚大学洛杉矶分校(物理系)博士

工作经历:

2012年10月-2015年02月美国加利福尼亚大学圣塔芭芭拉分校博士后研究员

2015年02月-2015年12月美国加利福尼亚大学圣塔芭芭拉分校助理研究员

2016年02月-2021年12月合肥工业大学副研究员

2021年12月至今合肥工业大学教授

2019年1月-2019年12月国家自然科学基金委员会农学与食品科学处兼聘

职务: 职称: 教授、博士生导师
所属系: 食品质量安全系 邮箱: quhao@hfut.edu.cn
办公地点: 食生楼602 学术成果 <br>瞿昊博士以构建食品生物传感的分子识别元件体系为核心内容,围绕如何发掘、优化与利用识别元件的基础“方法学”问题进行了系统研究。截止目前已在国际著名期刊如J. Am. Chem. Soc., ACS Nano, Phys. Rev. X, J. Agric. Food Chem., ACS Sens., Biosens. Bioelectron., Food Chem.等上发表第一作者或通讯作者高质量论文20余篇。研究成果入选J. Am. Chem. Soc., J. Agric. Food Chem., Talanta等封面,并受到科技日报头版、中国科学报、安徽日报、中新网、新华网、人民网、Science Trends等重要媒体报道。先后承担国家自然科学基金面上和青年项目、科技部重点研发计划子课题、安徽省科技重大专项、安徽省自然科学基金、中央高校基本业务费校级专项等项目。于第三届、第四届中国核酸适配体学术研讨会做大会报告,并任第四届会议学术委员会成员。申请发明专利5项,其中2项已授权;申请实用新型专利5项,其中3项已授权;参编国家标准2项。现任安徽省色谱分析学会理事。
代表性论文<br>
<br>第一作者论文:
<br>1.Hao Qu, Manyi Zheng, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng*, Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling, Angewandte Chemie International Edition, 2023, 62: e202214045.<br>
<br>2.Hao Qu*, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng, Measuring Aptamer Folding Energy Using a Molecular Clamp, Journal of the American Chemical Society, 2020, 142(27): 11743-11749.(封面论文)<br>
<br>3.Hao Qu, Andrew T. Csordas, Jinpeng Wang, Seung Soo Oh, Michael S. Eisenstein, Hyongsok Tom Soh*, Rapid and Label-Free Strategy to Isolate Aptamers for Metal Ions, ACS Nano, 2016, 10(8): 7558-7565. <br>
<br>4.Hao Qu, Giovanni Zocchi*, How Enzymes Work: A Look through the Perspective of Molecular Viscoelastic Properties, Physical Review X, 2013, 3: 011009. <br>
<br>5.Hao Qu, Yong Wang, Chiao-Yu Tseng, Giovanni Zocchi*, Critical torque for kink formation in double stranded DNA, Physical Review X, 2011, 1: 021008. <br>
<br>6.Hao Qu, Lu Wang*, Jian Liu*, Lei Zheng*, Direct Screening for Cytometric Bead Assays for Adenosine Triphosphate, ACS Sensors, 2018, 3(10): 2071–2078. <br>
<br>通讯作者论文:
<br>1.Songjia Luo#, Rongrong Wang#, Lu Wang#, Hao Qu*, Lei Zheng*, Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor, Biosensors & Bioelectronics, 2022, 210: 114319.<br>
<br>2.Yuhong Wang, Hao Qu*, Rongrong Wang, Baolei Dong, Lei Zheng*, Label-Free Biosensing of Mercury(II) in Milk Using an Aptamer-Gated Graphene Field-Effect Transistor, Journal of Electroanalytical Chemistry, 2022, 904: 115931. <br>
<br>3.Rongrong Wang, Yong Cao, Hao Qu*, Yanbo Wang, Lei Zheng*, Label-free detection of Cu(II) in fish using a graphene field-effect transistor gated by structure-switching aptamer probes, Talanta, 2022, 237: 122965.(封面论文,featured article)<br>
<br>4.Yuhong Wang, Yulong Bi, Rongrong Wang, Lu Wang, Hao Qu*, and Lei Zheng, DNA-Gated Graphene Field-Effect Transistors for Specific Detection of Arsenic(III) in Rice, Journal of Agricultural and Food Chemistry, 2021, 69(4): 1398–1404.(封面论文) <br>
<br>5.Rongrong Wang, Yuhong Wang, Hao Qu*, Lei Zheng*, An Acetylcholinesterase-Functionalized Biosensor for Sensitive Detection of Organophosphorus Pesticides Based on Solution-Gated Graphene Transistors, ACS Agricultural Science & Technology, 2021, 1, 372–378.<br>
<br>6.Rongrong Wang, Yu Mao, Lu Wang, Hao Qu*, Ying Chen, Lei Zheng*, Solution-gated graphene transistor based sensor for histamine detection with gold nanoparticles decorated graphene and multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2021, 347: 128980. <br>
<br>7.Yu Mao, Shengjie Gao, Lili Yao, Lu Wang, Hao Qu*, Yuen Wu, Ying Chen, Lei Zheng*, Single-atom nanozyme enabled fast and highly sensitive colorimetric detection of Cr(VI), Journal of Hazardous Materials, 2021, 408: 124898. <br>
<br>8.Shengjie Gao, Rongrong Wang, Yulong Bi, Hao Qu*, Ying Chen, Lei Zheng*, Identification of frozen/thawed beef based on label-free detection of hemin (Iron Porphyrin) with solution-gated graphene transistor sensors, Sensors & Actuators: B. Chemical, 2020, 305: 127167. <br>
<br>9.Yulong Bi, Lihui Ye, Yu Mao, Lu Wang*, Hao Qu*, Jian Liu*, Lei Zheng*. Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for ultrasensitive and real-time detection of lactic acid from cancer cell metabolism, Biosensors & Bioelectronics, 2019, 140: 111271. <br>
<br>10.Rongrong Wang, Yu Mao, Hao Qu*, Wei Chen, Aijin Ma, Lei Zheng*, Highly sensitive and selective sulfite sensors based on solution-gated graphene transistors with multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2019, 290: 101-106. <br>
<br>11.Can Xiong, Tengfei Zhang, Di Wang, Yi Lin, Hao Qu*, Wei Chen, Linbao Luo, Yanbo Wang, Lei Zheng*, Linglin Fu*, Highly sensitive solution-gated graphene transistor based sensor for continuous and real-time detection of free chlorine, Analytica Chimica Acta, 2018, 1033: 65-72. <br>
<br>12.Can Xiong, Tengfei Zhang, Weiyu Kong, Zhixiang Zhang, Hao Qu*, Wei Chen, Yanbo Wang, Linbao Luo, Lei Zheng*, ZIF-67 derived porous Co3O4 hollow nanopolyhedron functionalized solution-gated graphene transistors for simultaneous detection of glucose and uric acid in tears, Biosensors & Bioelectronics, 2018, 101: 21-28. <br>
<br>13.Can Xiong#, Yang Wang#, Hao Qu*, Lijun Zhang, Longzhen Qiu, Wei Chen, Feng Yan, and Lei Zheng*, Highly sensitive detection of gallic acid based on organic electrochemical transistors with poly(diallyldimethylammonium chloride) and carbon nanomaterials nanocomposites functionalized gate electrodes, Sensors & Actuators: B. Chemical, 2017, 246: 235-242. <br>
<br>14.Can Xiong, Hao Qu*, Wei Chen, Lijun Zhang, Longzhen Qiu, Lei Zheng*, Fan Xia, Real-time detection of Cu(II) with PEDOT:PSS based organic electrochemical transistors, Science China Chemistry, 2017, 60(9): 1205–1211.<br>

<br>发明专利
<br>1、一种快速检测牛肉冻融程度的方法,专利授权号:ZL201811643087.9.(第二发明人);<br>
<br>2、一种基于层状碳纳米片的酒精水凝胶传感设备及其方法,专利授权号:ZL202110052279.8(第二发明人)。<br>

<br>参编标准
<br>1、国家标准,《核酸适配体体外筛选技术导则》,GB/T 38137-2019,2019-10-18发布实施;<br>
<br>2、国家标准,《核酸适配体亲和性和特异性评价技术导则》,GB/T 40187-2021,2021-05-21发布,2021-12-01实施。
研究领域 <br>1、基于定向演化技术的分子识别元件高效发掘——功能核酸探针快速筛选方法;
<br>2、基于动态构型变化的分子识别元件性能优化——功能核酸探针结构-功能关联与调控;
<br>3、分子识别元件的高效利用——高性能生物传感器研究与开发。
<br>欢迎对分子生物学、食品质量安全及生物医药快速检测感兴趣的同学报考。
科研项目 <br>1、国家自然科学基金面上项目,32172294,快速检测乳品痕量重金属的适配体栅控石墨烯场效应传感器研究,2022.01 – 2025.12,58万元,在研,主持;
<br>2、国家重点研发计划项目子课题,2022YFB3207204,一站式新冠突变株快速筛查敏感元件构建及传感系统研制,2022.12 – 2024.05,160万元,在研,主持;
<br>3、安徽省科技重大专项公共竞争类项目,202003a06020017,皖北蛋鸡类无厨化中餐料理包全产业链营养品质变化和控制研究,2020.10 – 2023.09,120万元,在研,主持;
<br>4、国家自然科学基金青年项目,21705031,As(Ⅲ)依赖的RNA切割型脱氧核酶的磁珠展示快速定量筛选方法研究,2018.01 – 2020.12,23万元,结题,主持;
<br>5、安徽省自然科学基金青年项目,1808085QB39,核酸适配体环化反应及环状适配体性能研究,2018.07 – 2020.06,10万元,结题,主持;
<br>6、校级科学前沿创新专项,PA2019GDQT0018,数字化流式适配体免疫磁珠分析技术开发,2019.04 – 2020.12,30万元,结题,主持;
<br>7、校级学术新人提升B计划,JZ2017HGTB0195,基于核酸适配体修饰的有机电化学晶体管平台的重金属离子快速实时检测研究,2017.03 – 2018.12,20万元,结题,主持;
<br>8.技术合作开发项目,W2017JSKF0280,核酸适体筛选制备和活性评价的 2 项国家标准研制方法验证,2017.05 – 2017.06,1万元,结题,主持。
荣誉奖项 <br>1、安徽省色谱分析学会理事
<br>2、安徽省第八届“互联网+”大学生创新创业大赛高教主赛道银奖
<br>3、“古今贡酒年份原浆”杯安徽第五届工业设计大赛食品工业设计专项赛(三等奖)
<br>4、2019年合肥工业大学首届微结构摄影大赛(特等奖,优秀指导教师)

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